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 Prof. Renzo Cini
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| Prof. Renzo CINI |
Full Professor |
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| Dr. Gabriella TAMASI |
Grant Researcher |
METALS IN MEDICINE AND IN FOODS
Synthesis and structural characterization via X-ray diffraction, NMR, UV-vis, IR, EPR spectroscopic techniques, and molecular orbital, molecular mechanics and molecular dynamics methods of:
- novel series of metal (Pt, Ru, Cu, …) complexes with pharmacologically active molecules as ligands, i.e. anti-inflammatory drugs (oxicam family drugs, …), anti-tumoral drugs and anti-viral drugs, nucleobases and nucleotides, thiopurines, thiopyrimidines, …
- novel series of metal complexes with biological active ligands (i.e nucleic acid fragments) as models for metal interaction in biological systems
- novel series of organo-metallic compounds;
- cobalt complexes able to produce reversible adducts with molecular oxygen.
Studies of absorption and release from smart hydrogels of potential metal based drugs to examine possible delivery ways in human body.
Studies of interactions with DNA, proteins (albumin, transferrin, ...) of potential metal based drugs and cytotoxicity test against human tumor cell lines. In cooperation with other national and international research groups.
Theoretical studies of non-conventional hydrogen bond type interactions, chloride anion (C-H...Cl-, N-H...Cl-), Platinum-Purine/Pyrimidine complexes (C-H...N, C-H...S).
Studies of biomineralizations in rheumatic diseases to investigate of morphology, structure and solubility of crystals of sodium urate monohydrate (SHUM), hydroxylapatite (HAP), calcium pyrophosphate dihydrate (CPPD) obtained from in vitro experiments and from ex vivo samples. In cooperation with other national research groups.
Studies of essential and toxic metals (and other analites) in beverages, particularly drinking water, wines, grappa, ...
- Atomic Absorption Spectroscopy with flame and Electrothermal (furnace) atomization, and Mercury Hydride System
- HPLC, UV detector
- Ultraviolet-Visible Absorption Spectroscopy
CIADS
- X-ray diffractometer for single crystal Siemens P4
- GC-MS coupled Systems
COOPERATION LABORATORIES
- Infrared Absorption Spectroscopy Fourier Transform
- Nuclear Magnetic Resonance Spectroscopy (NMR)
- Inductively Coupled Plasma Mass Spectroscopy to the High Resolution (HR-ICP-MS)
- Scanning Electron Microscopy with X-ray Florescence MicroSound System
- Powder X-ray Diffraction Techniques
COMPUTERS
Chemical-Application packages:
- WinGX an integrated system of Windows programs for the solution, refinement and analysis of single crystal X-ray diffraction data
- HyperChem theoretical tool for the optimization and spectroscopic simulation of molecules;
- GAUSSIAN03 for the theoretical calculations via density functional and ab initio methods (from CINECA grants) and GaussView03 visualization package
- MacroModel for the structure optimizations via molecular mechanics methods
International Collaborations
| Prof Kenneth Hardcastle |
Emory University, Atlanta, Georgia, USA |
| Prof Michael B. Hursthouse |
University of Southampton,
Southampton, United Kingdom |
| Prof Luigi G. Marzilli |
Louisiana State University, Baton Rouge, Louisiana USA |
| Prof Keiji Morokuma |
Emory University, Atlanta, Georgia, USA |
National Collaborations
| Prof.Luigi Messori |
University of Firenze |
| Prof. Giovanni Natile |
University of Bari |
| Dr Roberto Netti |
Environmental protection Agency for Tuscany (Grosseto)
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Unisi Research Groups Collaborations
| Prof Mario Casolaro |
Department of Medicinal Chemistry |
| Prof Michele Gregorkiewitz |
Department of Earth Sciences |
| Prof Roberto Marcolongo |
Institute of Rheumatology, Polyclinic of Siena
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| Prof Agnese Magnani |
Department of Medicinal Chemistry |
| Prof Stefano Mangani |
Department of Chemistry |
| Prof Francesco Riccobono |
Department of Environmental Sciences |
| Prof Alessandro Sega |
Department of Medicinal Chemistry |
| Prof Gianni Valensin |
Department of Chemistry |
| Prof Piero Zanello |
Department of Chemistry |
Coordinator of programs for the Academic Cooperation Agreement between the University of Siena and Emory University (Atlanta, Georgia, USA) since 28 April 1977. The international agreement was established by the President of Emory University and the Magnifico Rettore on April 1997 and organize the exchange of not-graduated students, graduated students, teachers and researchers from all the disciplines from Emory to Siena and vice-versa. Since 2004, also Summer Schools Emory@Unisi and Unisi@Emory are carried out.
PUBLICATIONS
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